Methods for Efficient and Accurate Discovery of Services

With an increasing number of services developed and offered in an enterprise setting or the Web, users can hardly verify their requirements manually in order to find appropriate services. In this thesis, we develop a method to discover semantically described services. We exploit comprehensive service and request descriptions such that a wide variety of use cases can be supported. In our discovery method, we compute the matchmaking decision by employing an efficient model checking technique

Integrating Semantic Web Services Ranking Mechanisms Using a Common Preference Model

Service ranking has been long-acknowledged to play a fundamental role in helping users to select the best o erings among services retrieved from a search request. There exist many ranking mechanisms, each one providing ad hoc preference models that o er di erent levels of expressiveness. Consequently, applying a single mechanism to a particular scenario constrains the user to de ne preferences based on that mechanism's facilities. Furthermore, a more exible solution that uses several independent mechanisms will face interoperability issues because of the di erences between preference models provided by each ranking mechanism. In order to overcome these issues, we propose a Preference- based Universal Ranking Integration (PURI) framework that enables the combination of several ranking mechanisms using a common, holistic preference model. Using PURI, di erent ranking mechanisms are seamlessly and transparently integrated, o ering a single fa cade to de ne preferences using highly expressive facilities that are not only decoupled from the concrete mechanisms that perform the ranking process, but also allow to exploit synergies from the combination of integrated mechanisms. We also thoroughly present a particular application scenario in the SOA4All EU project and evaluate the bene ts and applicability of PURI in further domains

Opt-out as an acceptable method of obtaining consent in medical research: a short report

<p>Abstract</p> <p>Background</p> <p>A prospective cohort study was set up to investigate a possible association between antibiotic prescribing and antibiotic resistance of <it>E. coli </it>urinary tract infection in the community. Participation of patients with urinary tract infection was obtained through an opt-out methodology. This short paper reports on the acceptability of the opt-out recruitment approach.</p> <p>Methods</p> <p>Participating practices (22) were requested to send a urine sample from all patients presenting with symptoms of urinary tract infection. Upon receipt of the sample in the laboratory, a letter explaining the study, an opt-out form and a freepost envelope were sent to all adult patients. A website with additional information and including an 'opt-out' button was set up for the study.</p> <p>Results</p> <p>A total of 1362 urine samples were submitted by the 22 participating practices representing 1178 adult patients of whom 193 actively responded to the letter: 142 opted out by letter, 15 through the website, 2 by phone and 12 sent the letter back without indication, making a total of 171 patients or 14.5% opt-out; the remaining 22 patients (1.9%) explicitly opted in. The total group consisted of 80% women and the mean age was 50.9 years (sd 20.8). No significant differences were found between patients who participated and those who opted out in terms of age, gender or whether the urine sample was positive or not.</p> <p>Conclusions</p> <p>Overall the opt-out method was well received and participation in the study reached 85.5%. The low number of complaints (2) indicates that this is a generally acceptable method of patient recruitment. The 14.5% opt-out shows that it effectively empowers patients to decline participation. The similarity between patients opting out and the rest of the patients is reassuring for extrapolation of the results of the study.</p

Characterising restrictions on commercial advertising and sponsorship of harmful commodities in local government policies: a nationwide study in England.

BackgroundCommercial advertising and sponsorship drive the consumption of harmful commodities. Local authorities (LAs) have considerable powers to reduce such exposures. This study aimed to characterize local commercial policies across all English LAs.MethodsWe conducted a census of all English LAs (n = 333) to identify local commercial policies concerning advertising and sponsorship of tobacco, alcohol, less healthy foods and gambling, through online searches and Freedom of Information requests. We explored policy presence, commodity frequency and type, and associations with LA characteristics (region, urban/rural and deprivation).ResultsOnly a third (106) of LAs in England had a relevant policy (32%). These included restrictions on tobacco (91%), gambling (79%), alcohol (74%) and/or less healthy foods (24%). Policy prevalence was lowest in the East of England (22%), North East (25%) and North West (27%), higher in urban areas (36%) than rural areas (28%) and lower in the least (27%) compared with the most (38%) deprived areas. Definitions in policies varied, particularly for alcohol and less healthy foods.ConclusionsEnglish LAs currently underutilize their levers to reduce the negative impacts of harmful commodity industry marketing, particularly concerning less healthy foods. Standardized guidance, including clarity on definitions and application, could inform local policy development

Ethical issues in implementation research: a discussion of the problems in achieving informed consent

Background: Improved quality of care is a policy objective of health care systems around the world. Implementation research is the scientific study of methods to promote the systematic uptake of clinical research findings into routine clinical practice, and hence to reduce inappropriate care. It includes the study of influences on healthcare professionals' behaviour and methods to enable them to use research findings more effectively. Cluster randomized trials represent the optimal design for evaluating the effectiveness of implementation strategies. Various codes of medical ethics, such as the Nuremberg Code and the Declaration of Helsinki inform medical research, but their relevance to cluster randomised trials in implementation research is unclear. This paper discusses the applicability of various ethical codes to obtaining consent in cluster trials in implementation research. Discussion: The appropriate application of biomedical codes to implementation research is not obvious. Discussion of the nature and practice of informed consent in implementation research cluster trials must consider the levels at which consent can be sought, and for what purpose it can be sought. The level at which an intervention is delivered can render the idea of patient level consent meaningless. Careful consideration of the ownership of information, and rights of access to and exploitation of data is required. For health care professionals and organizations, there is a balance between clinical freedom and responsibility to participate in research. Summary: While ethical justification for clinical trials relies heavily on individual consent, for implementation research aspects of distributive justice, economics, and political philosophy underlie the debate. Societies may need to trade off decisions on the choice between individualized consent and valid implementation research. We suggest that social sciences codes could usefully inform the consideration of implementation research by members of Research Ethics Committees

Resonance strengths in the 14N(p, \gamma)15O and 15N(p, \alpha \gamma)12C reactions

The 14N(p, \gamma)15O reaction is the slowest reaction of the carbon-nitrogen-oxygen cycle of hydrogen burning in stars. As a consequence, it determines the rate of the cycle. The 15N(p, \alpha \gamma)12C reaction is frequently used in inverse kinematics for hydrogen depth profiling in materials. The 14N(p, \gamma)15O and 15N(p, \alpha \gamma)12C reactions have been studied simultaneously, using titanium nitride targets of natural isotopic composition and a proton beam. The strengths of the resonances at Ep = 1058 keV in 14N(p, \gamma)15O and at Ep = 897 and 430 keV in 15N(p, \alpha \gamma)12C have been determined with improved precision, relative to the well-known resonance at Ep = 278 keV in 14N(p, \gamma)15O. The new recommended values are \omega \gamma = 0.353$\pm$0.018, 362$\pm$20, and 21.9$\pm$1.0 eV for their respective strengths. In addition, the branching ratios for the decay of the Ep = 1058 keV resonance in 14N(p, \gamma)15O have been redetermined. The data reported here should facilitate future studies of off-resonant capture in the 14N(p, \gamma)15O reaction that are needed for an improved R-matrix extrapolation of the cross section. In addition, the data on the 430 keV resonance in 15N(p, \alpha \gamma)12C may be useful for hydrogen depth profiling.Comment: 10 pages, 8 figures. Corrected typos in the abstract, table IV made more comprehensible. As accepted in Phys.Rev.

Visual performance and ocular abnormalities in deaf children and young adults: a literature review

Visual defects are common in deaf individuals. Refractive error and ocular motor abnormalities are frequently reported, with hyperopia, myopia, astigmatism and anomalies of binocular vision, all showing a greater prevalence in deaf individuals compared with the general population. Near visual function in deaf individuals has been relatively neglected in the literature to date. Comparisons between studies are problematic due to differences in methodology and population characteristics. Any untreated visual defect has the potential to impair the development of language, with consequences for education more generally, and there is a need to improve screening and treatments of deaf children. © 2013 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd